Open AccessExperimental assessment of the KK1 peptide effectiveness for prevention of the CNS delayed impairments after acute intoxication with carbon monoxide
Author(s) -
П. Г. Толкач,
Vadim A. Basharin,
A. N. Grebenyuk,
Alexandre Alexandrovich Kolobov
Publication year - 2015
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf13329-34
Subject(s) - tetrapeptide , carbon monoxide poisoning , antidote , carbon monoxide , chemistry , co poisoning , neuropsychology , peptide , anesthesia , pharmacology , medicine , toxicity , poison control , biochemistry , organic chemistry , psychiatry , medical emergency , cognition , catalysis
Intoxication with the carbon monoxide leads to the development the early and delayed neuropsychological impairments. Oxygen therapy is used usually as an antidote for the treatment of acute carbon monoxide poisoning. The synthetic analogues of endogenous peptides were shown to prevent the neuropsychological impairments. One of them is KK1, a tetrapeptide acetyl-(D-Lys)-Lys-Arg-Arg-amide, assessed as a structural analogue of corticotropine. The efficiency of the synthetic tetrapeptide KK1 for the prevention of the CNS delayed impairments after acute carbon monoxide poisoning has been evaluated in this study.