Open AccessAntihypoxic effects of new metal-complex copper-containing substances
Author(s) -
D.V. Sosin,
Сосин Денис Владимирович,
Olga Eugenievna Shalayeva,
Шалаева Ольга Евгеньевна,
А. В. Евсеев,
Евсеев Андрей Викторович
Publication year - 2015
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf13318-23
Subject(s) - copper , chemistry , hypoxia (environmental) , energy metabolism , metabolism , pharmacology , oxygen , biochemistry , endocrinology , biology , organic chemistry
In experiments on mice in 3 different models of acute exogenous hypoxia, 12 new substances concerning to a group of copper-containing physiologically compatible antioxidants were investigated. It was discovered that substances πQ262, πQ1077 А and πQ1079 А significantly increase lifetime of mice during development of all used variants of hypoxias. On the example of the most active agents in the studied group (πQ262, πQ1077 A, πQ1079 A) shows that their anti-hypoxic effect on the development of acute exogenous hypoxia is accompanied by a marked decrease in the standard of energy metabolism, as well as a significant inhibitory effect on the state of the cardio-respiratory system of experimental animals. The obtained results allow attributing such substances as πQ262, πQ1077 А and πQ1079 А to the antihypoxant group of metabolic action.