Neurochemical mechanisms of the cerebroprotective action of spiro[indole-3,1'-pyrrol [3,4-с] pyrrol] derivative | Zendy

Ol'ga Vital'yevna Khodakovskaya | Zendy; Д. В. Евдокимов | Zendy; Sergey Yur'yevich Shtrygol' | Zendy; И. И. Абрамец | Zendy; Leonid Borisovich Braverman | Zendy; Aleksey Anatol'yevich Khodakovskiy | Zendy; Ruslan Grigor'yevich Red'kin | Zendy

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Neurochemical mechanisms of the cerebroprotective action of spiro[indole-3,1'-pyrrol [3,4-с] pyrrol] derivative

Author(s) -

Ol'ga Vital'yevna Khodakovskaya,

Д. В. Евдокимов,

Sergey Yur'yevich Shtrygol',

И. И. Абрамец,

Leonid Borisovich Braverman,

Aleksey Anatol'yevich Khodakovskiy,

Ruslan Grigor'yevich Red'kin

Publication year - 2015

Publication title -

reviews on clinical pharmacology and drug therapy

Language(s) - English

Resource type - Journals

eISSN - 2542-1875

pISSN - 1683-4100

DOI - 10.17816/rcf13156-61

Subject(s) - nmda receptor , neuroprotection , postsynaptic potential , neurotoxicity , neurochemical , chemistry , hippocampal formation , pharmacology , indole test , derivative (finance) , stereochemistry , receptor , neuroscience , biochemistry , biology , toxicity , organic chemistry , financial economics , economics

The mechanisms of the neuroprotective effect of 3,2’-spiro-pyrrolo-2-оxindole derivative (code number R-86) were investigated in hippocampal sections of rats by measuring the amplitude of postsynaptic potentials in pyramidal neurons. In vitro R-86 reduced the responces to NMDA-receptors activation as well as hydrogen peroxide-induced injury, being not active in anoxia and neuroglycopenia. When systemically administered, R-86 exerted weak effect in anoxia and neuroglycopenia and decreased steroid-induced neurotoxicity.

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