Open AccessNeurochemical mechanisms of the cerebroprotective action of spiro[indole-3,1'-pyrrol [3,4-с] pyrrol] derivative
Author(s) -
Ol'ga Vital'yevna Khodakovskaya,
Ходаковская Ольга Витальевна,
Д. В. Евдокимов,
Евдокимов Дмитрий Владимирович,
S. Yu. Shtrygol,
Штрыголь Сергей Юрьевич,
И. И. Абрамец,
Абрамец Игорь Игоревич,
Leonid Borisovich Braverman,
Браверман Леонид Борисович,
Aleksey Anatol'yevich Khodakovskiy,
Ходаковский Алексей Анатольевич,
Ruslan Gr. Redkin,
Редькин Руслан Григорьевич
Publication year - 2015
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf13156-61
Subject(s) - nmda receptor , neuroprotection , postsynaptic potential , neurotoxicity , neurochemical , chemistry , hippocampal formation , pharmacology , indole test , derivative (finance) , stereochemistry , receptor , neuroscience , biochemistry , biology , toxicity , organic chemistry , financial economics , economics
The mechanisms of the neuroprotective effect of 3,2’-spiro-pyrrolo-2-оxindole derivative (code number R-86) were investigated in hippocampal sections of rats by measuring the amplitude of postsynaptic potentials in pyramidal neurons. In vitro R-86 reduced the responces to NMDA-receptors activation as well as hydrogen peroxide-induced injury, being not active in anoxia and neuroglycopenia. When systemically administered, R-86 exerted weak effect in anoxia and neuroglycopenia and decreased steroid-induced neurotoxicity.