Kisspeptins in physiology and pathology of sex development - new diagnostic and therapeutic approaches | Zendy

Irina L. Nikitina | Zendy; Alekber Azizovich Bayramov | Zendy; Yuliya Nikolaevna Khoduleva | Zendy; Petr Dmitriyevich Shabanov | Zendy

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Kisspeptins in physiology and pathology of sex development - new diagnostic and therapeutic approaches

Author(s) -

Irina L. Nikitina,

Alekber Azizovich Bayramov,

Yuliya Nikolaevna Khoduleva,

Petr Dmitriyevich Shabanov

Publication year - 2014

Publication title -

reviews on clinical pharmacology and drug therapy

Language(s) - English

Resource type - Journals

eISSN - 2542-1875

pISSN - 1683-4100

DOI - 10.17816/rcf1243-12

Subject(s) - kisspeptin , sexual differentiation , neuroscience , medicine , biology , bioinformatics , physiology , genetics , gene , hypothalamus

The article is dedicated to mechanisms of the human reproductive system development mechanisms. The evolution of the opinions on that processes was analysed. The review of modern knowledge of molecular and genetic causes of sex development, new mechanisms of gonadal axis regulation and role of kisspeptins in pubertat start and sexual differentiation of the brain are presented. The new actual directions of scientific research as well as the applications of kisspeptin drugs for new therapeutic approaches, treatment of hormone-dependent diseases and abnormalities of sex developmentare are observed.

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