Open AccessKisspeptins in physiology and pathology of sex development - new diagnostic and therapeutic approaches
Author(s) -
И. Л. Никитина,
Alekber Azizovich Bayramov,
Yuliya Nikolaevna Khoduleva,
Petr Dmitriyevich Shabanov
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf1243-12
Subject(s) - kisspeptin , sexual differentiation , neuroscience , medicine , biology , bioinformatics , physiology , genetics , gene , hypothalamus
The article is dedicated to mechanisms of the human reproductive system development mechanisms. The evolution of the opinions on that processes was analysed. The review of modern knowledge of molecular and genetic causes of sex development, new mechanisms of gonadal axis regulation and role of kisspeptins in pubertat start and sexual differentiation of the brain are presented. The new actual directions of scientific research as well as the applications of kisspeptin drugs for new therapeutic approaches, treatment of hormone-dependent diseases and abnormalities of sex developmentare are observed.