Open AccessRole of reactive oxygen species in cell physiology and pathology and their pharmacological regulation
Author(s) -
В. Е. Новиков,
О. С. Левченкова,
Yelena Vasilyevna Pozhilova
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf12413-21
Subject(s) - reactive oxygen species , function (biology) , antioxidant , cell function , neuroscience , physiology , bioinformatics , biology , medicine , microbiology and biotechnology , cell , biochemistry
This review is devoted to analysis of modern scientific investigations about role of reactive oxygen species (ROS) in physiology and pathophysiology of cell. Key issues of ROS generation, their function in signaling pathways, role in the cellular pathology, functioning of antioxidant system are discussed in the paper. The review also summarizes literature data about possibility of pharmacological regulation of the activity of free radical oxidation reactions, which have practical value for effective pharmacotherapy of diseases in pathogenesis of which destructive action of ROS is present.