Open AccessInfluence of substance πQ1983 on evoked potentials of somatosensory cortex during acute hypoxia development
Author(s) -
D.V. Sosin,
Andrey Viktorovich Yevseyev,
В. А. Правдивцев,
Marina Anatolyevna Yevseyeva,
Petr Dmitriyevich Shabanov
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf12341-49
Subject(s) - hypoxia (environmental) , cats , somatosensory system , respiration , somatosensory evoked potential , anesthesia , chemistry , hypoxic hypoxia , substance p , medicine , oxygen , neuroscience , anatomy , biology , hypothermia , receptor , organic chemistry , neuropeptide
The influence of selenium-containing metal-complex substance πQ1983 on somatosensory cortex bioelectrical activity has been studied on cats (n = 22) during development of acute hypoxia. The condition of acute hypoxia was performed by making of loop including an animal, an apparatus for artificial lung ventilation, and a reservoir for respiration with 5 liter volume. Evoked activities of neurons were provided by direct electrical current irritations applied to the radial nerve of right superior extremity. Couple needle-shaped electrodes were used for mean evoked potentials registration. 100 mg/kg of the substance πQ1983 was introduced in the stomach 180 min before experiment. Also on any steps of the experiments ECG was registered. Containing of oxygen and carbon dioxide were determined by method of gas analysis in air enabled for respiration. It have been established that the substance πQ1983 taking internally increases cortex neurons functional activity period more than triple during acute hypoxia, stabilizes myocardial electrical activity, and helps animals to sustain the action of critical oxygen and carbon dioxide concentrations. Finally, the substance πQ1983 may be related to the high effectively antihypoxants because it significantly rises the resistance of animals with high CNS organization level (cats) to the acute hypoxia even after introduction per os.