Open AccessThe regulatory role of mitochondrial pora and the possibility of its pharmacological modulation
Author(s) -
Yelena Vasilyevna Pozhilova,
В. Е. Новиков,
О. С. Левченкова
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf12313-19
Subject(s) - mptp , neuroscience , mitochondrion , apoptosis , mitochondrial permeability transition pore , biology , microbiology and biotechnology , pharmacology , medicine , programmed cell death , biochemistry , dopaminergic , dopamine
The review is devoted to the role of mitochondrial Ca2+-dependent pore (mPTP) in the regulation of metabolic processes in cells under physiological and pathological conditions. The mechanisms of reperfusion injury in the postischemic period involving mPTP are discussed in the paper. The possibilities of pharmacological regulation of metabolic and functional processes in cells by target action on mPTP work are assessed. This approach allows to regulate key cell functions, stimulating either mechanisms of adaptation and survival in extreme conditions or apoptosis. Pharmacological modulators of the mitochondrial pore as drugs have promising value for treatment of ischemic diseases as well as tumor therapy.