Open AccessExperimental investigation of the lipin gravidoprotective action in the model of placental disfunction caused by oxidative stress
Author(s) -
Olesya Viktorovna Kudina
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf12259-64
Subject(s) - placenta , placental insufficiency , oxidative stress , drug , endocrinology , organogenesis , medicine , kidney , action (physics) , pregnancy , pharmacology , biology , fetus , biochemistry , genetics , gene , physics , quantum mechanics
In the model of placental insufficiency caused by tetrachlormethane during organogenesis in rats, a pronounced effect of the gravidoprotective drug lipin was found assessed in their ability to prevent intrauterine growth retardation of rats and to normalize the morphological changes in the liver, kidney and placenta of pregnant rats. The drug lipin exceeds the reference drug essentiale on the sum of these indicators.