Open AccessCharacteristics of external respiration of rats in acute hypercapnic hypoxia and its correction by new metal-complex antihypoxant
Author(s) -
D.V. Sosin,
Сосин Денис Владимирович,
Andrey Viktorovich Yevseyev,
Евсеев Андрей Викторович,
В. А. Правдивцев,
Правдивцев Виталий Андреевич,
Petr Dmitriyevich Shabanov,
Шабанов Петр Дмитриевич
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf12236-42
Subject(s) - hypercapnia , respiration , hypoxia (environmental) , chemistry , oxygen , respiratory system , substance p , anesthesia , medicine , biochemistry , anatomy , receptor , organic chemistry , neuropeptide
Changes of external respiration parameters have been studied in experimental rats after oral introduction of new selenium-containing metal-complex substance πQ1983 in dose 100 mg/kg before and under action of acute hypercapnic hypoxia (AH+Hc). A substance for comparison was metabolic antihypoxant amthizole administered in similar way and dosage. The substances were introduced 90 min before (incubation period) placement of animals into hypoxic chambers with 1.0 L free volume. During each experiment as well as during AH+Hc a respiration curve called pneumobarogramm (PBG) was recorded continually. It has been established that the substance πQ1983 decreases parameters of lungs ventilation in the rats. According to PBG dynamics, rats protected by the substance demonstrated a high resistance level to the aroused acute hypoxia with hypercapnia, that expressed by weakening of early reactions from respiratory system under hypercapnia action, twice longer life span of animals in hypoxic experiment, and by rising of possibility to withstand low oxygen concentration. It has been proved that the substance πQ1983 significantly surpass a substance for comparison amthizole in both antihypoxic activity and influence on external respiration parameters.