Open AccessStructure, functions of p-glycoprotein and its role in rational pharmacotherapy
Author(s) -
E. N. Yakusheva,
A V Shulkin,
Н. М. Попова,
Ivan Vladimirovich Chernyh,
Д С Титов
Publication year - 2014
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf1223-11
Subject(s) - p glycoprotein , glycoprotein , pharmacotherapy , transporter , pharmacology , computational biology , neuroscience , biology , medicine , chemistry , biochemistry , multiple drug resistance , gene , antibiotics
In the review of literature, the structure and functions of P-glycoprotein are characterized, features of its substrates, inductors and inhibitors and possibility of forecasting of belonging to them new medicinal substances are described, molecular mechanisms of activity changes of the transporter under the influence of various factors are presented.