Structure, functions of p-glycoprotein and its role in rational pharmacotherapy | Zendy

E. N. Yakusheva | Zendy; A V Shulkin | Zendy; N. M. Popova | Zendy; Ivan Vladimirovich Chernyh | Zendy; Д С Титов | Zendy

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Structure, functions of p-glycoprotein and its role in rational pharmacotherapy

Author(s) -

E. N. Yakusheva,

A V Shulkin,

N. M. Popova,

Ivan Vladimirovich Chernyh,

Д С Титов

Publication year - 2014

Publication title -

reviews on clinical pharmacology and drug therapy

Language(s) - English

Resource type - Journals

eISSN - 2542-1875

pISSN - 1683-4100

DOI - 10.17816/rcf1223-11

Subject(s) - p glycoprotein , glycoprotein , pharmacotherapy , transporter , pharmacology , computational biology , neuroscience , biology , medicine , chemistry , biochemistry , multiple drug resistance , gene , antibiotics

In the review of literature, the structure and functions of P-glycoprotein are characterized, features of its substrates, inductors and inhibitors and possibility of forecasting of belonging to them new medicinal substances are described, molecular mechanisms of activity changes of the transporter under the influence of various factors are presented.

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