Open AccessThe role of neurotransmitter systems separate the hemispheres of the brain in action the new antiepileptic compounds AGB-31
Author(s) -
Oleg Aleksandrovich Yarosh
Publication year - 2013
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf11231-35
Subject(s) - glutamate decarboxylase , chemistry , glutathione , glutamate receptor , neurotransmitter , lateralization of brain function , medicine , endocrinology , neuroscience , biochemistry , psychology , biology , enzyme , receptor
Compound AGB-31, a monocarbamate derivative, is shown to possess a high antiepileptic activity. The mechanisms of antiepileptic action are connected with significant increase in glutamic acid decarboxylase activity in the left hemisphere of the brain, with trend of the glutamate content decrease in the left hemisphere and the tendency to increase GABA in both hemispheres. AGB-31 significantly (more than 3-fold) increases syntase nitric oxide activity in the left hemisphere and has a tendency to reduce the NO content in both hemispheres. AGB-31 significantly (by 63.4%), reduced glutathione peroxydase activity in the right hemisphere without changing it in the left, with a tendency to increase the activity of glutathione reductase in both hemispheres.