Open AccessUsage of warfarin as a reference drugin experiments on rats
Author(s) -
Dmitriy Yuryevich Ivkin,
A. V. Buryakina,
Irina Leonidovna Stepanova,
A. S. Ivkina
Publication year - 2013
Publication title -
reviews on clinical pharmacology and drug therapy
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf11146-49
Subject(s) - warfarin , anticoagulant , medicine , pharmacology , atrial fibrillation
The possibility of using indirect anticoagulant warfarin as a reference drug in sсreening researches on rats was considered in the article. The dose of warfarin leading to true increase of prothrombine time without any internal gemorrhagias in animals has been defined. The optimal terms of administration for warfarin were defined. The dose-dependent regularity of warfarin effect from its duration of administration to rats was revealed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom