Open AccessUsage of warfarin as a reference drugin experiments on rats
Author(s) -
Dmitriy Yuryevich Ivkin,
Ивкин Дмитрий Юрьевич,
A. V. Buryakina,
Бурякина Анна Вениаминовна,
Irina Leonidovna Stepanova,
Степанова Ирина Леонидовна,
А. С. Ивкина,
А. С. Ивкина
Publication year - 2013
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf11146-49
Subject(s) - warfarin , anticoagulant , medicine , pharmacology , atrial fibrillation
The possibility of using indirect anticoagulant warfarin as a reference drug in sсreening researches on rats was considered in the article. The dose of warfarin leading to true increase of prothrombine time without any internal gemorrhagias in animals has been defined. The optimal terms of administration for warfarin were defined. The dose-dependent regularity of warfarin effect from its duration of administration to rats was revealed.