Open AccessExpediency of application of animals with the spontaneous hypertensia for modelling of the metabolic syndrome
Author(s) -
M.А. Kovaleva,
М.Н. Макарова,
A. I. Selezneva,
V.G. Makarov
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10491-94
Subject(s) - cafeteria , metabolic syndrome , blood pressure , medicine , endocrinology , obesity , pathogenesis , calorie , cholesterol , physiology , pathology
When used within 11 weeks of diet “cafeteria diet” in spontaneously-hypertensive animals could lead to an increase in systolic blood pressure by 9%, sustained hyperglycemia, increased blood concentrations of triglycerides and cholesterol, as well as an increase in the relative content of visceral fat. In normotensive animals line Wistar-Kyoto prolonged use of “cafeteria diet” was accompanied only by an increase in blood glucose, cholesterol and triglycerides. Thus, the spontaneously hypertensive animals, the application of high-calorie diet demonstrated by three criteria pathogenesis of the metabolic syndrome: hyperglycemia, hypertension and visceral obesity, which allows you to use the model for the study of drugs aimed at treatment of metabolic syndrome.