Open AccessHYPOTHERMIC EFFECT OF ANTIHYPOXANTS πQ1983 AND πQ2170
Author(s) -
D.V. Sosin,
Andrey Viktorovich Yevseyev,
Э. А. Парфенов,
В. А. Правдивцев,
Marina Anatolyevna Yevseyeva,
Petr Dmitriyevich Shabanov
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10478-82
Subject(s) - rectal temperature , enteral administration , selenium , toxicity , acute toxicity , chemistry , toxicology , pharmacology , medicine , anesthesia , parenteral nutrition , biology , organic chemistry
In experiments on mice the influence of the new antihypoxants (selenium containing metal complex substances πQ1983, πQ2170) on rectal temperature level dynamic after parenteral and enteral introductions was studied. It is established that both substances perform clear dose-dependent hypothermic effect exceeding an action of the antihypoxant amthizole. Was supposed that substance πQ2170 has high acute toxicity affirmed by significant mice death-rate.