HYPOTHERMIC EFFECT OF ANTIHYPOXANTS πQ1983 AND πQ2170 | Zendy

D.V. Sosin | Zendy; Andrey Viktorovich Yevseyev | Zendy; Edgar Andreyevich Parfenov | Zendy; В. А. Правдивцев | Zendy; Marina Anatolyevna Yevseyeva | Zendy; Petr Dmitriyevich Shabanov | Zendy

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HYPOTHERMIC EFFECT OF ANTIHYPOXANTS πQ1983 AND πQ2170

Author(s) -

D.V. Sosin,

Andrey Viktorovich Yevseyev,

Edgar Andreyevich Parfenov,

В. А. Правдивцев,

Marina Anatolyevna Yevseyeva,

Petr Dmitriyevich Shabanov

Publication year - 2012

Publication title -

reviews on clinical pharmacology and drug therapy

Language(s) - English

Resource type - Journals

eISSN - 2542-1875

pISSN - 1683-4100

DOI - 10.17816/rcf10478-82

Subject(s) - rectal temperature , enteral administration , selenium , toxicity , acute toxicity , chemistry , toxicology , pharmacology , medicine , anesthesia , parenteral nutrition , biology , organic chemistry

In experiments on mice the influence of the new antihypoxants (selenium containing metal complex substances πQ1983, πQ2170) on rectal temperature level dynamic after parenteral and enteral introductions was studied. It is established that both substances perform clear dose-dependent hypothermic effect exceeding an action of the antihypoxant amthizole. Was supposed that substance πQ2170 has high acute toxicity affirmed by significant mice death-rate.

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