Open AccessTHE MOLLUSC IONIC CURRENTS CHANGES AFTER ADMINISTRATION OF N-PHENYLALKYL DERIVATIVES OF TAURINE
Author(s) -
А. И. Вислобоков,
Л. К. Хныченко,
Yuriy Dmitriyevich Ignatov,
Н. С. Сапронов,
Petr Dmitriyevich Shabanov
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10467-72
Subject(s) - lymnaea stagnalis , taurine , chemistry , membrane potential , biophysics , intracellular , extracellular , potassium , sodium , calcium , ionic bonding , biochemistry , ion , biology , snail , amino acid , ecology , organic chemistry
The transmembrane sodium, potassium and calcium ionic currents were studied after extracellular administration of N-phenylalkyl derivatives of taurine in concentrations 1, 10, 100 and 1000 mM. The method of intracellular dialysis with fixed membrane potential was used in model of isolated neurons of the mollusks Lymnaea stagnalis and Planorbarius corneus. The solutions containing 1 and 10 mM of the compounds studied did not change ionic channels activity in isolated neurons. Concentrations 100 and mM depressed reversibly all currents in the dose-dependent manner: taurine < TAU-02 < TAY-15 < TAU-60. The voltage-amplitude membrane characteristics as well as kinetics of the currents did not change.