Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment | Zendy

Vasiliy Yegorovich Novikov | Zendy; Sergey Alekseyevich Ilyukhin | Zendy; Yelena Vasilyevna Pozhilova | Zendy

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Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment

Author(s) -

Vasiliy Yegorovich Novikov,

Sergey Alekseyevich Ilyukhin,

Yelena Vasilyevna Pozhilova

Publication year - 2012

Publication title -

reviews on clinical pharmacology and drug therapy

Language(s) - English

Resource type - Journals

eISSN - 2542-1875

pISSN - 1683-4100

DOI - 10.17816/rcf10463-66

Subject(s) - inflammation , edema , pharmacology , anti inflammatory , inflammatory response , chemistry , enteral administration , medicine , parenteral nutrition

The dynamics of the acute inflammatory response was observed in the experiment modeling caragenin-induced rat paw inflammation. The changes in the volume of damaged limb (paw edema) and indices of free radical oxidation were registered. Acetylsalicylic acid in the dose of 100 mg/kg was shown to reduce the development of inflammation. Hypoxen and metaprot in the dose of 50 mg/kg have got low anti-inflammatory activity, but potentiated the effect of acetylsalicylic acid. Simultaneous enteral administration of hypoxen and metaprot with the acetylsalicylic acid during the treatment with caragenin the powerful anti-inflammatory effect was marked, it was presented with a significant decrease in the parameters of inflammation recorded and rapid recovery of the damaged limb. The combination of hypoxen with acetylsalicylic acid was the most effective one.

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