Open AccessSAFETY OF NEW SUBSTANCES WITH PROTECTIVEACTIVITY IN ACUTE EXOGENOUS HYPOXIA
Author(s) -
D.V. Sosin,
Andrey Viktorovich Yevseyev,
Petr Dmitriyevich Shabanov
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10458-62
Subject(s) - hypoxia (environmental) , acute toxicity , enteral administration , pharmacology , medicine , chemistry , intensive care medicine , toxicology , biology , oxygen , toxicity , parenteral nutrition , organic chemistry
In the article are represented results of both acute toxicities and safety determination of selenium-containing metal-complex substances πQ1983, πQ2170 that have high pharmacological activities in acute exogenous hypoxia after their introperitoneal or enteral introductions in mice. According with established parameters LD50 the couple of studied substances must be referred to the category of high toxic chemical agents. However, substance πQ1983 can be recommended for its preclinical investigation because it has enough permissible parameters of ED50 and therapeutic indexes.