Open AccessEffect of general vibration on functions of breath chain in the rabbit parenchimatic organs
Author(s) -
Viktoriya Vladimirovna Vorobyeva,
Воробьева Виктория Владимировна,
V. G. Khorobrykh,
V. G. Khorobrykh,
Petr Dmitriyevich Shabanov,
Шабанов Петр Дмитриевич
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10416-29
Subject(s) - mitochondrion , oxidative phosphorylation , nad+ kinase , chemistry , polarography , medicine , respiratory chain , liver tissue , succinate dehydrogenase , biochemistry , vibration , endocrinology , biophysics , biology , physics , inorganic chemistry , enzyme , quantum mechanics
The purpose of the paper was to study the activity of energy producing system of the rabbit liver and ren after exposure to general vibration of different type regimens. The energy dependent reactions of native mitochondria were investigated by means of polarographic method using Clark’s closed membrane electrode. The energy producing system of the liver and ren was shown to be involved in response reaction of the organism on vibration exposure. The degree of functional activity of the liver and ren mitochondria depended on the studied regimens of vibration (frequency and duration) and manifested with misbalance between FAD- and NAD-depended links of the breath chain. The increase in frequency and duration of vibration led to low energetic shift with activation of the oxidative system for succinate and the inhibition of NAD-depended link of the breath chain in mitochondria as well as with dystrophy of the liver tissue.