Open AccessStudy of antihypoxic activities of metal complex selenium containing substances after their parenteral and enteralintroductions
Author(s) -
D.V. Sosin,
Сосин Денис Владимирович,
Andrey Viktorovich Yevseyev,
Евсеев Андрей Викторович,
Э. А. Парфенов,
Парфенов Эдгар Андреевич,
В. А. Правдивцев,
Правдивцев Виталий Андреевич,
Marina Anatolyevna Yevseyeva,
Евсеева Марина Анатольевна,
Petr Dmitriyevich Shabanov,
Шабанов Петр Дмитриевич
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10328-34
Subject(s) - selenium , hypoxia (environmental) , hypothermia , chemistry , medicine , pharmacology , anesthesia , oxygen , organic chemistry
In experiments on mice undergone to an acute hypercapnic hypoxia and an acute hypobaric hypoxia a screening of antihypoxants among new selenium containing metal complex substances was performed after their intra-abdominal and oral introductions. It was found that substances πQ1983 and πQ2170 on both models of hypoxia make the defensive effects surpassing actions well-known antihypoxants such as amthizole and bemythil. It was shown that antihypoxiс affects of studied substances depend on their caused hypothermia. For the first time the protective action of selenium containing metal complex compounds was demonstrated after their introduction per os.