Open AccessClinical pharmacology of cartilageprotectors
Author(s) -
Pavel Vasilyevich Rodichkin,
Nikolay Sergeyevich Shalamanov
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10318-27
Subject(s) - cartilage , synovial fluid , glycosaminoglycan , metabolism , excretion , pharmacology , medicine , chemistry , osteoarthritis , biochemistry , pathology , anatomy , alternative medicine
Cartilage protectors improve a cartilage metabolism, reduce or interrupt its destruction and render partial anti-inflammatory effect. Not only the preparations which are the structural analogues of the such cartilaginous tissue principal components as glycosaminoglycans (proteoglycans), but also other preparations of vegetative or animal origin having an impact on cartilage metabolism and proteolytic enzyme activity. Nutrients intake and metabolites excretion are achieved with joint movement with direct involvement of synovial fluid. For achievement of the highest therapeutic effect it must be borne in mind doses of preparations and to practice regular physical exercises. Methods of manual therapy and electroneurostimulation are effectively applied to restoration of the movement pattern lost as a result of disease.