Open AccessPROGNOSIS OF PHYSICOCHEMICAL FEATURES AND PHARMACOLOGICAL EFFECTS OF 2,6-DI-TERT-BUTYLREPLACED THIO(AMINO)ALKYLPHENOLS
Author(s) -
E. I. Terakh,
Терах Елена Игоревна,
Alexandr Yvgenyevich Prosenko,
Просенко Александр Евгеньевич
Publication year - 2012
Publication title -
obzory po kliničeskoj farmakologii i lekarstvennoj terapii
Language(s) - English
Resource type - Journals
eISSN - 2542-1875
pISSN - 1683-4100
DOI - 10.17816/rcf10214-19
Subject(s) - lipophilicity , thio , chemistry , biological activity , amino acid , phenols , solubility , organic chemistry , biochemistry , in vitro
The calculation of physicochemical parameters and biological activities has been conducted for 11 2,6-di-tert-butylreplaced thio(amino)alkylphenols by means of computer programs ALOGPS, GUSAR and PASS. It is shown that phenols are characterized by their lower water solubility, higher lipophilicity, they are weak and middle toxic substances (4th and 5th danger class), they possess neither mutagenic nor teratogenic effect. The thio(amino)alkylphenols biological activity estimation indicated that they can be considered as potential means for treatment of free radical pathologies. The gained results of the prognosis open wide medical and biological potentials of thio(amino)alkylphenols and may serve as a theoretical base for planning further experimental re-searches in biological systems.