Open AccessProspects of hydroxyapatite-based nanomaterials application synthesized by layer-by-layer method for pediatric traumatology and orthopedics
Author(s) -
Aleksandra A. Meleshko,
Мелешко Александра Александровна,
Valeri P. Tolstoy,
Толстой Валерий Павлович,
Г. Е. Афиногенов,
Афиногенов Геннадий Евгеньевич,
Aleksandra Levshakova,
Левшакова Александра Сергеевна,
А. Г. Афиногенова,
Афиногенова Анна Геннадьевна,
Vladislav P. Muldiyarov,
Мульдияров Владислав Павлович,
Sergei V. Vissarionov,
Виссарионов Сергей Валентинович,
С А Линник,
Линник Станислав Антонович
Publication year - 2020
Publication title -
ortopediâ, travmatologiâ i vosstanovitelʹnaâ hirurgiâ detskogo vozrasta
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.157
H-Index - 4
eISSN - 2410-8731
pISSN - 2309-3994
DOI - 10.17816/ptors33824
Subject(s) - materials science , nanotechnology , layer by layer , nanomaterials , hydroxyapatites , layer (electronics) , nanometre , surface modification , nanoparticle , substrate (aquarium) , adsorption , chemical engineering , composite material , chemistry , metallurgy , organic chemistry , engineering , calcium , oceanography , geology
The present brief review focuses on the features of the Layer-by-Layer (LbL) synthesis of coatings containing hydroxyapatite nanoparticles and assesses their use in solving several biomedical problems. This work provides the state-of-art of this field. This method is based on the sequential chemical adsorption of reagents on the substrate surface that makes it possible to apply nanolayers of the specified composition on the surface of a wide range of substrates of complex shape, to control the thickness of the synthesized layers accurately at the nanometer level. It also enables the modification of surface characteristics, including roughness, hydrophilicity, and surface charge, and allows artificially constructed multilayers consisting of hybrid organic and inorganic substances to be obtained. The experimental material presented in the review demonstrates the effectiveness of LbL synthesis for creating new 3D scaffolds as bone substitutes, coatings on the surface of metal implants, and drug delivery systems. A promising direction for the development of LbL synthesis is the creation of methods that involve ion-substituted hydroxyapatites as reagents. Success in this area can pave the way for significant advances in biomedicine and open new opportunities for creating a new generation of structures that mimic the structural, compositional, and mechanical properties of the bone mineral phase.