Open AccessIntegral leukocgram indices in children with coronavirus infection COVID-19
Author(s) -
K. S. Korotaeva,
Е. Г. Фурман,
O N Sumlivaya
Publication year - 2022
Publication title -
permskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1408
pISSN - 0136-1449
DOI - 10.17816/pmj39127-34
Subject(s) - medicine , convalescence , covid-19 , immunology , monocyte , index (typography) , gastroenterology , infectious disease (medical specialty) , disease , world wide web , computer science
Objective. To study the changes in hematological leukocyte indices among children with coronavirus infection COVID-19 in the dynamics of infectious process.
Materials and methods. The work is based on the analysis of clinical and laboratory data from 91 pediatric patients with COVID-19. On the basis of a general blood test, the following hematological leukocyte indices were determined: the entropy degree of leukogram according to A.V. Gorelov et al.; leukocyte intoxication index according to V.K. Ostrovsky; nuclear endotoxicosis degree index according to G.D. Dashtayants; Harkavi adaptation index; Krebs index; leukocyte index; neutrophils to monocytes ratio index; lymphocytes to monocytes ratio index.
Results. The most sensitive hematological indices were the entropy degree of leukogram according to A.V. Gorelov et al., indicating a violation of the dynamic constancy of leukogram; neutrophils to monocytes ratio indices, lymphocytes to monocytes ratio indices, showing the presence of a viral infection. At the peak of the infectious process, C-reactive blood protein index significantly correlated with the endotoxicosis index according to G.D. Dashtayants (R = 0.271; p0.05), with neutrophils to monocytes ratio index (R = 0.276; p0.05); and in the period of early convalescence - with leukocyte intoxication index according to V.K. Ostrovsky (R = 0.743; p0.05), with endotoxicosis indices according to Dashtayants (R = 0.785; p0.05) and neutrophils to monocytes ratio index (R = 0.743; p0.05).
Conclusions. The calculation of hematological leukocyte indices increases the information capability of the general blood test in children with coronavirus infection COVID-19, provides important additional information on intoxication syndrome, the state of immune response, the persistence of inflammatory process during the period of convalescence as well.