Open AccessEffect of pregravid preparation of HIV-infected couples on perinatal outcomes
Author(s) -
A. O. Ovchinnikova,
S. V. Mikhalchenko,
M.A. Kaganova,
O. E. Chernova
Publication year - 2021
Publication title -
permskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1408
pISSN - 0136-1449
DOI - 10.17816/pmj3856-14
Subject(s) - medicine , pregnancy , obstetrics , human immunodeficiency virus (hiv) , cohort , viral load , second trimester , gynecology , immunology , gestation , genetics , biology
Objective. To assess the levels of viral load, immune status as well as labor outcome depending on the absence or presence of pregravid preparation with the partner and without the latter.
Materials and methods. This cohort study included 90 women of reproductive age with stages 3 and 4A HIV infection. To compare the groups, Kruskal Wallis, Mann Whitney tests and correlation analysis were applied.
Results. The pregravid preparation of HIV-infected women without a partner was detected to three-fold decrease a viral load in the I trimester of pregnancy (p = 0.001), two-fold in the II trimester (p = 0.02) and three-fold in the III trimester (p = 0.002); with a partner a two-fold decrease in the I trimester (p = 0.0018). The pregravid preparation of HIV-infected women reduces the probability of giving birth to a child with low body mass (p = 0.023); with a partner it decreases the risk for the preterm labor (p = 0.02).
Conclusions. Thus, the presence of pregravid preparation in HIV-infected women, with a partner as well, decreases the probability of giving birth to a child with low body mass and preterm labor.