Open AccessExosomes and myocardial infarction: scientific and practical interest
Author(s) -
О. В. Хлынова,
R. A. Rodionov,
Н. С. Карпунина,
Ekaterina Shishkina
Publication year - 2021
Publication title -
permskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1408
pISSN - 0136-1449
DOI - 10.17816/pmj38476-84
Subject(s) - microvesicles , medicine , myocardial infarction , pathophysiology , immune system , pathological , infarction , inflammation , bioinformatics , cardiology , immunology , pathology , microrna , biology , biochemistry , gene
A review of the literature on the biological role of exosomes in the pathophysiology of a number of pathological conditions, including damage to the heart muscle in the variant of myocardial infarction (MI), is presented. In the last decade, exosomes have begun to be actively studied; a lot of data have appeared on their nature and role in intercellular transport and signaling both in normal conditions and in pathology. Exosomes are important carriers of biological information, facilitating intercellular communication and participating in the pathophysiology of various cardiovascular diseases. In myocardial infarction, massive cardiomyocyte death triggers a strong inflammatory response, which is a vital process for cardiac damage, repair, and remodeling. A growing body of evidence suggests that exosomes are involved in the inflammatory response and immune regulation after MI.