Open AccessFeatures of formation of biliary dysfunctions in children consuming drinking water with high nitrate content
Author(s) -
Olga G. Tolmacheva,
Толмачева Ольга Геннадьевна,
О.Yu. Ustinova,
Устинова Ольга Юрьевна,
Olga A. Maklakova,
Маклакова Ольга Анатольевна,
Yulia A. Ivashova,
Ивашова Юлия Анатольевна,
Alexsandra Yu. Vandisheva,
Вандышева Александра Юрьевна
Publication year - 2019
Publication title -
permskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1408
pISSN - 0136-1449
DOI - 10.17816/pmj36565-70
Subject(s) - medicine , nitrate , hemoglobin , hemolysis , gastroenterology , urine , gallbladder , nitrite , jaundice , physiology , zoology , ecology , biology
. In recent years, there is more and more information about the global distribution of nitrates in soil, water, food.
Purpose. To study the features of the formation of biliary dysfunction in children with drinking water with high nitrate content.
Materials. 124 school-age children consuming drinking water with high nitrate content (1.3 MPC) were examined. The comparison group included 52 children living in areas where the nitrate level in drinking water was 4.7 times lower. Results. In children of the observation group, the concentration of N-nitrosodimethylamine in the blood was 3.3 times higher than in the comparison group, and the concentration of nitrates in urine was 1.8 times higher. Every second child with a pathology of the gastrointestinal tract consuming drinking water with a high content of nitrates was diagnosed with biliary dysfunction manifested by hepatocellular dysfunction (increased activity of AST) and a violation of motor-tonic function of the gallbladder by hyperkinetic type against the background of hemolysis of erythrocytes (increased total bilirubin) with a stable level of hemoglobin.