Open AccessFeatures of species composition of intestinal bifidobacterium and microbial metabolism profile in children of the first half of life depending on the way of delivery
Author(s) -
Е. М. Булатова,
Булатова Елена Марковна,
Alexandr M. Shabalov,
Шабалов Александр Михайлович,
Н.М. Богданова,
Богданова Наталья Михайловна,
Alexandr I. Shilov,
Шилов Александр Игоревич,
Emma G. Oganesiyan,
Оганесян Эмма Гагиковна,
Nadezhda S. Kuritsyna,
Курицина Надежда Станиславовна
Publication year - 2018
Publication title -
pediatr
Language(s) - English
Resource type - Journals
eISSN - 2587-6252
pISSN - 2079-7850
DOI - 10.17816/ped9111-16
Subject(s) - bifidobacterium , breastfeeding , feces , caproic acid , valeric acid , bifidobacterium breve , medicine , formula feeding , composition (language) , acetic acid , butyric acid , food science , zoology , physiology , chemistry , biology , pediatrics , microbiology and biotechnology , biochemistry , lactobacillus , fermentation , linguistics , philosophy
Changes of intestinal microbiome in first year of life, related with cesarean section, are the most unfavorable and have long-term negative immunological and metabolic effects. The aim of the study. Evaluate the species composition of Bifidobacterium, range of Short-chain Fatty Acids (SCFA) in feces in children, who were born by natural way or with cesarean section, for clarification their diagnostic value in the process of formation of microbiocenosis in children. Materials and methods. Exa mined 60 children in the age of 4-6 months. 48 children were born in natural way and 12 were born by cesarean section. All of them were full-term and were on breastfeeding. Functional disorders of digestion were noted in 49 children (81,7%). Researchs that were conducted: microbiological examination of feces, typing of Bifidobacterium (PCR), definition of SCFA (C2 – acetic acid, C3 – propionic acid, C4 – butyric acid, C5 – valeric acid, C6 – caproic acid) content in feces. Results. III-grade dysbiotic changes in intestines were found significantly less in natural-way born (NW) children in comparison with cesarean section (CS) born children (14,58 и 33,33%; p 0,05). Established, that content of acetic acid was significantly higher in NW born children (1,59 ± 0,75 и 1,04 ± 0,56; p < 0,05). Conclusion. In CS born children, impoverishment of the intestines by infantile species of Bifidobacterium, lower content of acetic acid, were detected significantly more often. It shows decrease of activity and amount of obligatory anaerobic bacteria (Bifidum-, Lacto-) in intestines, increased activity of opportunistic flora. That can be used in practical healthcare with diagnostic purpose.