Open AccessSTUDY OF THE DOSE-DEPENDANT CARDIOPROTECTIVE EFFECTS OF MACROLIDES
Author(s) -
Е. С. Черноморцева,
T. G. Pokrovskaya,
E. B. Artushkova,
M. V. Pokrovsky,
В. В. Гуреев,
Yu. V. Legkova
Publication year - 2009
Publication title -
rossijskij mediko-biologičeskij vestnik imeni akademika i. p. pavlova/rossijskij mediko-biologičeskij vestnik imeni akademika i.p. pavlova
Language(s) - English
Resource type - Journals
eISSN - 2500-2546
pISSN - 0204-3475
DOI - 10.17816/pavlovj2016484-87
Subject(s) - ventricle , myocardial infarction , pharmacology , lethality , dose dependence , medicine , necrosis , chemistry , cardiology , toxicology , biology
In laboratory animals is carried out a study of the dose-dependant cardioprotective effects of the group of modern macrolides with the simulation of the coronaroocclusional myocardial infarction. The preparations being investigated effectively decrease lethality and decrease the zone of the necrosis of left ventricle after coronaroocclusion. The dose-dependant effects are expressed in groups of 14- and 15- member macrolides.