Comparative pathophysiological characteristic of intraocular immunological changes in open globe injury in the experiment at intravitreal and periocular administration of depot glucocorticoids

One of the most severe types of eye trauma - open globe injury - is a serious medical and societal problem. Short-acting glucocorticosteroids (dexamethasone and others) were widely used in open globe injury treatment. Over the last several years ophthalmologists treating this problem have used depot corticosteroids (triamcinolone acetonide and others), which have a pronounced anti-inflammatory effect and do not require multiple injections. However, up to now, there is no consensus concerning the route of depot steroids administration to patients with open globe injuries. In the present study, in experiments on rabbits, a comparative assessment of the influence of intravitreal and periocular triamcinolone acetonide administration on intraocular immunologic reactions during acute period of open globe injury was evaluated.