Open AccessTHE COMPARISON OF DIFFERENT DRUG DELIVERY METHODS OF LEVOFLOXACIN IN THE ANTERIOR CHAMBER
Author(s) -
Ernest V. Boiko,
Diana Vladimirovna Fokina,
Vladimir Alexeevich Reituzov,
С. И. Алекперов
Publication year - 2013
Publication title -
oftalʹmologičeskie vedomosti
Language(s) - English
Resource type - Journals
eISSN - 2412-5423
pISSN - 1998-7102
DOI - 10.17816/ov2013225-29
Subject(s) - levofloxacin , aqueous humor , polyvinyl alcohol , drug , pharmacology , minimum inhibitory concentration , contact lens , drug delivery , medicine , antibiotics , ophthalmology , chromatography , biomedical engineering , chemistry , materials science , nanotechnology , biochemistry , organic chemistry
In this research we compare the efficiency of noninvasive intraocular-delivering methods of different dosage forms of levofloxacin (LF) with the help of soft contact lens (SCL) and eye drops of LF and LF with the presence of prolongator — hypromellose. It is revealed, that SCL saturated with levofloxacin achieve therapeutic concentration in aqueous humor. This is due to the gradual release of antibiotic from the SCL in the anterior chamber. Installations of eye drops of LF and LF with hypromellose achieve minimum inhibitory concentration of fluoroquinolone in aqueous humor during 3 and 5 hours respectively. It is discussed the using of each dosage form in preventive and therapeutic purposes.