S. D. Vladychko. To the pathology of the spinal cord in scleroderma. Kiev. University. Izvestia № 3 of 1908

The object of the author's observations was a patient with pronounced scleroderma covering almost the entire surface of the body. At the same time it was possible to state - goiter, seborrhoeam on the forehead and steatorrhoeam on the body, anhidrosim and a decrease in reflexes. Movement in the joints of the extremities by means of a gradual restriction became completely impossible towards the end of the patient's life. The muscles of the limbs atrophied, and the atrophy was degenerative in nature. The patient died in a state of deep cachexia - with symptoms of a decline in cardiac activity. The disease lasted only ten months.