Comt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (Science. — 2003. —Feb. 21. — 299(5610). — P. 1240—1243: англ.) | Zendy

Jon-Kar Zubieta | Zendy; Mary M. Heitzeg | Zendy; Yoav Smith | Zendy; Joshua A. Bueller | Zendy; Ke Xu | Zendy; Yongxin Xu | Zendy; R. Коерре | Zendy; Christian S. Stohler | Zendy; David Goldman | Zendy

Open Access

Comt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (Science. — 2003. —Feb. 21. — 299(5610). — P. 1240—1243: англ.)

Author(s) -

Jon-Kar Zubieta,

Mary M. Heitzeg,

Yoav Smith,

Joshua A. Bueller,

Ke Xu,

Yongxin Xu,

R. Коерре,

Christian S. Stohler,

David Goldman

Publication year - 2003

Publication title -

neurology bulletin

Language(s) - English

Resource type - Journals

eISSN - 2304-3067

pISSN - 1027-4898

DOI - 10.17816/nb89679

Subject(s) - catechol o methyl transferase , neurotransmitter , stressor , opioid , dopamine , psychology , endorphins , gene , neuroscience , endocrinology , genotype , medicine , genetics , biology , receptor , central nervous system

The catechol-O-methyl-transferase (COMT) gene regulates the metabolic processes of the neurotransmitter dopamine and, through it, influences endorphins, which play an important role in the process of pain perception. It was found that the COMT gene with the amino acid valine (val158) is more active than the variant of the gene containing methionine (met158).

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