Open AccessComt val158met genotype affects mu-opioid neurotransmitter responses to a pain stressor (Science. — 2003. —Feb. 21. — 299(5610). — P. 1240—1243: англ.)
Author(s) -
Jon-Kar Zubieta,
Mary M. Heitzeg,
Yoav Smith,
Joshua A. Bueller,
Ke Xu,
Yongxin Xu,
R. Коерре,
Christian S. Stohler,
David Goldman
Publication year - 2003
Publication title -
nevrologičeskij vestnik
Language(s) - English
Resource type - Journals
eISSN - 2304-3067
pISSN - 1027-4898
DOI - 10.17816/nb89679
Subject(s) - catechol o methyl transferase , neurotransmitter , stressor , opioid , dopamine , psychology , endorphins , gene , neuroscience , endocrinology , genotype , medicine , genetics , biology , receptor , central nervous system
The catechol-O-methyl-transferase (COMT) gene regulates the metabolic processes of the neurotransmitter dopamine and, through it, influences endorphins, which play an important role in the process of pain perception. It was found that the COMT gene with the amino acid valine (val158) is more active than the variant of the gene containing methionine (met158).