Open AccessTo the question of study of epileptogenic role of kynurenine in the epileptic pathogenesis (clinical and biochemical study)
Author(s) -
С. А. Громов,
I. P. Lapin,
Е. А. Fedotenkova
Publication year - 1997
Publication title -
nevrologičeskij vestnik
Language(s) - English
Resource type - Journals
eISSN - 2304-3067
pISSN - 1027-4898
DOI - 10.17816/nb79874
Subject(s) - kynurenine , kynurenine pathway , pathogenesis , epilepsy , medicine , immunology , chemistry , tryptophan , psychiatry , biochemistry , amino acid
It was studied the content of endogenic convulsive agent, kynurenine, in the blood and liquor of 57 epileptic patients. It was revealed raising of kynurenine level in the blood of epileptic patients as compared with the level of control group, as well as more high level of kynurenine in the blood of patients with frequent seizures and lowering its level in liquor just after paroxysm. The abovesaid confirms the certain role of kynurenine in the pathogenesis of epilepsy.