Open AccessEeg-analysis of the effect of combined use of carbamazepin and mexidolum on the epileptiform brain activity
Author(s) -
О. L. Badalyan,
Л. Н. Неробкова,
Т. А. Воронина,
G. N. Avakyan
Publication year - 1997
Publication title -
nevrologičeskij vestnik
Language(s) - English
Resource type - Journals
eISSN - 2304-3067
pISSN - 1027-4898
DOI - 10.17816/nb79866
Subject(s) - hippocampal formation , epilepsy , pharmacology , electroencephalography , drug , anesthesia , hippocampus , phenobarbital , medicine , cortex (anatomy) , neuroscience , psychology
Experiments on rats with chronic epileptogenic fod in sensomotor region of cortex showed that effects of anticonvulsive agents depend on the progression phase of epileptic system. Effect of carbamasepinum in effective doses is mostly expressed during the phase of stable epileptic system with
determinant foci in limbico-hypothalamic structures. Lowering the doses of the drug brings about a decrease of anticonvulsive effect and activation of the secondary hippocampal focus. Combined use of carbamazepin and mexidolum with membra-notropic antioxidantal activity bbrings about an increase of anticonvulsive properties of carbamazepin and allows to decrease the therapeutic doses of the last.