Open AccessPatogenetic motivation of using the calcium antagonists in treatment hypoxic intracranial hemorrhages in newborns
Author(s) -
Г. А. Иваничев,
Г. А. Иваничев,
Е. В. Левитина,
Е. В. Левитина,
M. M. Minnibaev,
M. M. Minnibaev
Publication year - 2001
Publication title -
nevrologičeskij vestnik
Language(s) - English
Resource type - Journals
eISSN - 2304-3067
pISSN - 1027-4898
DOI - 10.17816/nb79731
Subject(s) - hypoxia (environmental) , medicine , encephalopathy , calcium , pathological , nimodipine , tissue hypoxia , hypoxic ischemic encephalopathy , calcium in biology , physiology , anesthesia , chemistry , organic chemistry , oxygen , erythropoietin
The prospective observation, clinical and biochemical examination of 252 mature infants with perinatal hypoxic encephalopathy from neonatal period till 1 years old and 55 infants with intracranial hemorrhages were carried out. The role of perinatal risk factors in the pathological forming as well as the dependence of clinical manifestations from hypoxia character (acute, chronic, combined) and the disease period was determined. The interrelation of disturbances of enzyme transmembrane transport of electrolytes activity and the level of intracellular calcium in thrombocytes with the character, degree of the severity, clinical syndromes and course of pathological process was revealed. The decrease of Ca2+-ATPase activity and increase of the level of intracellular calcium in patients with the chronic and combined character of hypoxia was noted. Clinical and biochemical efficiency of calcium antagonists (nimodipine) in children with perinatal hypoxic and hemorrhagic CNS disturbances was determined.