Open AccessRole evaluation of autoimmune inflammatory reaction in cerebral ischemia pathogenesis
Author(s) -
G N Zhdanov,
Margarita M. Gerasimova
Publication year - 2003
Publication title -
nevrologičeskij vestnik
Language(s) - English
Resource type - Journals
eISSN - 2304-3067
pISSN - 1027-4898
DOI - 10.17816/nb100104
Subject(s) - pathogenesis , cerebrospinal fluid , medicine , ischemia , inflammation , antibody , immunology , neurology , pathology , psychiatry
Monitoring of contents of antibodies to deoxyribonucleic acid in cerebrospinal fluid and in blood serum at dynamics of acute ischemic insult has been done. It was noticed a reliable increase of antibody level to deoxyribonucleic acid during the first 24 hours of cerebral ischemia both in the blood serum and in the cerebrospinal fluid. Increase is shown untill the 10th day, and then there is a decrease. It should be noted that the higher antibody levelis the more neurology deficit is expressed and the prognosis is worse. The performed clinical and immunologic study confirmed a role of autoimmune reactions and caused by them a local inflammation in pathogenesis of ischemic insult and infarction alterations formations in the brain tissue.