Open AccessLATE-ONSET HYPOGONADISM EFFECTS ON CORONARY HEART DISEASE
Author(s) -
С Б Шустов,
В П Кицышин,
Д С Фролов,
А.В. Макарова
Publication year - 2017
Publication title -
vestnik severo-zapadnogo gosudarstvennogo medicinskogo universiteta im. i.i. mečnikova
Language(s) - English
Resource type - Journals
eISSN - 2618-9704
pISSN - 2618-7116
DOI - 10.17816/mechnikov20179128-33
Subject(s) - medicine , cardiology , coronary artery disease , subclinical infection , depression (economics) , testosterone (patch) , ejection fraction , st depression , androgen , heart failure , st segment , myocardial infarction , hormone , economics , macroeconomics
A total of 161 men with at a mean age of 58 (52; 64) years were available for examination. Sixty of them presented with coronary artery disease and confirmed late-onset hypogonadism, 80 had coronary artery disease and normal testosterone, 21 had no coronary artery disease and no hypogonadism. The study included echocardiography, Holter monitoring, heart computed tomography, coronarography and estimation of depression level. We found that low testosterone in patients with coronary artery disease is associated with decreased left ventricular ejection fraction, atypical anginal syndrome and subclinical depression. Men with androgen deficiency and ischemic heart disease have lower heart rate variability, longer time of ST interval depression and greater amount of extrasystoles, than patients with ischemic heart disease and no androgen deficiency. There is a negative correlation between total testosterone and amount of myocardial revascularisation operations in men with normal testosterone. Patients with free testosterone 9pg/ml according to coronary angiography.