Open AccessCLINICAL SIGNIFICANCE OF MICRORNA-21 ExPRESSION IN MONITORINGOF TUMOR PROGRESSION WITH CEREBRAL GLIOMAS
Author(s) -
R. Yu. Seliverstov,
M I Zarayskiy,
Alexei A Sazanov,
Е. Е. Зуева,
S V Lobzyn,
А. Ф. Гурчин,
N V Sterlikova,
К П Гайдаенко,
M B Volov,
O I Tymonina,
N V Tolstyh
Publication year - 2015
Publication title -
vestnik severo-zapadnogo gosudarstvennogo medicinskogo universiteta im. i.i. mečnikova
Language(s) - English
Resource type - Journals
eISSN - 2618-9704
pISSN - 2618-7116
DOI - 10.17816/mechnikov20157447-51
Subject(s) - glioma , tumor progression , medicine , clinical significance , brain tumor , pathology , microrna , oncology , cancer research , biology , cancer , gene , biochemistry
The early verifying of cerebral’s gliomas progression is an actual problem. It was found that the level of mircroRNA-21 expression is a highly specific in a tumor’s evolutional process. That the aim of the study was the assessment with level of mircroRNA-21 expression in blood and saliva of patients with cerebral glioma progression and patients without it which were verified by PET using [11C] methionine. It was found that in majority of cases, the negative dynamics of cerebral neoplastic lesions coincided with an increase in metabolic changes in the residual glioma and highly correlated with the level of mircroRNA-21 expression. This allows us to consider a highly significant the level of mircroRNA-21 expression as a screening technique in monitoring the evolution of the tumor process and the effectiveness of the treatment.