Open AccessCLINICAL AND IMMUNOLOGICAL INTERACTIONS IN THE RECURRENT MISCARRIAGEAND THEIR CORRECTION METHODS
Author(s) -
M A Belyaeva,
Sergey Aleksandrovich Bobrov,
С. В. Лапин
Publication year - 2015
Publication title -
vestnik severo-zapadnogo gosudarstvennogo medicinskogo universiteta im. i.i. mečnikova
Language(s) - English
Resource type - Journals
eISSN - 2618-9704
pISSN - 2618-7116
DOI - 10.17816/mechnikov201573118-123
Subject(s) - immune system , immunology , pregnancy , medicine , human chorionic gonadotropin , antibody , fetus , abortion , etiology , anti nuclear antibody , reproductive immunology , biology , autoantibody , reproductive technology , genetics , lactation
The review is devoted to the problem of reproductive losses associated with impairment of the immune mechanisms which ensure the normal pregnancy progression. Increased expression of cytokines by T-helper type 1 cells underlies the immune etiology of reproductive losses. Decrease in regulatory T- cells activity leads to the development of recurrent spontanious abortion . The most important mechanisms of pregnancy progression cytokine regulation are presented. The main autoimmune conditions leading to fetal death are: antiphospholipid syndrome, increased activity of natural killer cells, compatibility in the HLA system, the presence of antinuclear, antigiston, sperm antibodies and Human chorionic gonadotropin antibodies. The modern methods of pathogenetic therapy of recurrent spontanious abortion are reviewed.