Open AccessInfluence of mesenchymal stem therapy on the behavior of the process of sam-rats with brain injury
Author(s) -
Т. В. Авалиани,
Авалиани Татьяна Варламовна,
O. R. Fedotova,
Федотова Ольга Ростиславовна,
Sergey G. Tsikunov,
Цикунов Сергей Георгиевич
Publication year - 2020
Publication title -
medicinskij akademičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1378
pISSN - 1608-4101
DOI - 10.17816/maj34103
Subject(s) - mesenchymal stem cell , offspring , open field , transplantation , medicine , neuroscience , traumatic brain injury , stem cell , psychology , physiology , pathology , surgery , biology , pregnancy , psychiatry , genetics
Current research suggests the potential use of mesenchymal stem cells (MSCs) in the treatment of brain injuries. Intravenous administration of MSCs to adult rats with brain injury leads to the restoration of behavioral and neurological status and helps to normalize maternal behavior. In this work, it was shown that a single transplantation of syngeneic mesenchymal stem cells (5 mln) into the bloodstream of female rats with motor deficiency has a corrective effect on the behavior of their offspring: it prevents the development of violations of research and locomotor behavior in the Open Field test and reduces emotional disorders.