Influence of mesenchymal stem therapy on the behavior of the process of sam-rats with brain injury | Zendy

Т. В. Авалиани | Zendy; O. R. Fedotova | Zendy; Sergey G. Tsikunov | Zendy

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Influence of mesenchymal stem therapy on the behavior of the process of sam-rats with brain injury

Author(s) -

Т. В. Авалиани,

O. R. Fedotova,

Sergey G. Tsikunov

Publication year - 2020

Publication title -

medical academic journal

Language(s) - English

Resource type - Journals

eISSN - 2687-1378

pISSN - 1608-4101

DOI - 10.17816/maj34103

Subject(s) - mesenchymal stem cell , offspring , open field , transplantation , medicine , neuroscience , traumatic brain injury , stem cell , psychology , physiology , pathology , surgery , biology , pregnancy , psychiatry , genetics

Current research suggests the potential use of mesenchymal stem cells (MSCs) in the treatment of brain injuries. Intravenous administration of MSCs to adult rats with brain injury leads to the restoration of behavioral and neurological status and helps to normalize maternal behavior. In this work, it was shown that a single transplantation of syngeneic mesenchymal stem cells (5 mln) into the bloodstream of female rats with motor deficiency has a corrective effect on the behavior of their offspring: it prevents the development of violations of research and locomotor behavior in the Open Field test and reduces emotional disorders.

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