Open AccessEDITING THE BEHAVIOR OF EXPERIMENTAL ANIMALS MODULATED IN VITRO BY IMMUNE CELLS
Author(s) -
M. A. Knyazheva,
М. А. Княжева,
E. V. Serenko,
E. V. Serenko,
Г. С. Карпович,
Г. С. Карпович
Publication year - 2019
Publication title -
medicinskij akademičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1378
pISSN - 1608-4101
DOI - 10.17816/maj191s1149-151
Subject(s) - immune system , open field , in vitro , cytokine , transplantation , chlorpromazine , motor behavior , medicine , neuroscience , pharmacology , immunology , psychology , biology , biochemistry
The aim of the study is to edit the hyperactive behavior in experiments using immunocyte transplantation using in vitro modules with neuroleptic functional activity. Materials and methods. Experimental model: male mice (CBAxC57Bl/6) F1 of three months of age with hyperactive behavior. Immune cells were treated with chlorpromazine in a test tube, injected intravenously into the recipient, in which the behavior parameters in the open field test and the cytokine content in the brain were determined by ELISA. Results. Transplantation of precision and neuroleptic components contained in recipient mice is accompanied by a decrease in the indices of research and motor components, as well as the levels of IL-1β, IL-6 and TNFα cytokines in the brain.