Open AccessROLE OF THE HYPOTHALAMIC-PITUITARY-GONADAL SYSTEM IN THE PATHOGENESIS OF ALZHEIMER’S DISEASE
Author(s) -
О. О. Масалова,
О. О. Масалова,
S. B. Kazakova,
S. B. Kazakova,
Н. С. Сапронов,
Н. С. Сапронов
Publication year - 2018
Publication title -
medicinskij akademičeskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2687-1378
pISSN - 1608-4101
DOI - 10.17816/maj18116-26
Subject(s) - disease , dementia , medicine , neuroscience , alzheimer's disease , pathogenesis , bioinformatics , psychology , biology
Alzheimer's disease (AD) is the most common from degenerative diseases of cerebrum which lead to the development of dementia. Because the exact causes of contraction of Alzheimer's disease (AD) are unknown, there is no adequate etiotropic therapy for this serious disease. Modern drugs present on the market, including cholinesterase inhibitors and NMDA antagonists, only alleviate symptoms without affecting the progression of AD. The review presents the results of modern studies confirming the significant contribution of gonadotropinreleasing hormone, gonadotropins and sex steroids to the development of mental aging. It is emphasized that the study of the role of the hypothalamic-pituitary-gonadal system in the etiopathogenesis of AD is certainly a promising area of psychoneuroendocrinology, which, perhaps, will lead to the development of new approaches to the treatment of this neurodegenerative disease. The contradictoriness of the data of a number of studies is noted and discussed.