Open AccessClinical and microbiologic evaluation of current treatments for bacterial vaginosis
Author(s) -
M A Gamzaev,
Гамзаев Мехман Агаверди Оглы,
E M Novruzov,
Новрузов Ельшад Мирзали оглы
Publication year - 2013
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kmj2174
Subject(s) - bacterial vaginosis , medicine , metronidazole , suppository , population , vaginal discharge , vagina , gynecology , antibiotics , surgery , microbiology and biotechnology , biology , pharmacology , environmental health
Aim. To circle out the population at risk for bacterial vaginosis, and to evaluate the effect of the most promising treatments for this disease.Methods. 298 women, including 143 pregnant women, aged 18 to 45 years, with abnormal discharge from the genital tract underwent clinical, microbiologic, and gynecologic examination and were questioned about the history of the disease. The results were compared with 34 healthy controls. Vaginal swabs were taken and stained by Gram, microorganisms and key cells were calculated at microscopy, vaginal pH was measured. The tests were repeated at 1 and 6-7 months after treatment.Results. The effect of metronidazole (500 mg vaginal suppository twice daily for 5 days) was 75.3±4.9%, of chlorhexidine (16 mg vaginal suppository twice daily for 5 days) - 89.4±3.8% (р 0.05). Relapses at 6-7 months after treatment were registered in 22.1±4.8 and 7.6±3.3% of pregnant patients (р 0.02).Conclusion. Local use of metronidazole and chlorhexidine in patients with bacterial vaginosis is highly effective, has no serious side effects (including in pregnant patients) and leads to constant vaginal microbiota normalization.