Open AccessA case of arterial thrombosis with formation of an atypical fibrin-rich thrombus
Author(s) -
Rafael R. Khismatullin,
Хисматуллин Рафаэль Рафикович,
А. З. Шакирова,
Шакирова Ася Закиевна,
Alina D. Peshkova,
Пешкова Алина Дмитриевна,
Anvar N. Khuziakhmedov,
Хузиахмедов Анвар Наилевич,
S M Khizriev,
Хизриев Сейфедин Магомедович,
Rustem I. Litvinov,
Литвинов Рустем Игоревич
Publication year - 2018
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kmj2018-994
Subject(s) - thrombus , fibrin , thrombosis , platelet , medicine , cardiology , venous thrombosis , artery , pathology , immunology
Aim. To describe a case of arterial thrombosis with a thrombus that had atypical composition due to profound pathological changes in the cellular and protein composition of the blood. Methods. Scanning electron microscopy of an ex vivo thrombus extracted from the common femoral artery. Results. In the absence of platelets and leukocytes there was a significant prevalence of fibrin over other blood components in all layers of the arterial thrombus. There were no morphological signs of intravital contraction (retraction) characteristic for thrombi: single erythrocytes were not exposed compressive deformation, redistribution of fibrin and platelets within the thrombus toward the periphery. Formation of the atypical arterial thrombus in the vessel with atherosclerotic vessel damage is probably due to association with severe hyperfibrinogenemia and thrombocytopenia. Conclusion. The structure of a thrombus depends not only on its vascular location (arterial or venous), but also on the cellular and protein composition of the blood. These factors support diversification of antithrombotic therapy, considering composition and properties of thrombi irrespective of the place and hemodynamic conditions of their formation.