Open AccessDiagnostic value of vascular endothelial growth factor determination in chronic pyelonephritis in children
Author(s) -
V V Bazarny,
Базарный Владимир Викторович,
М В Аверченко,
Аверченко Маргарита Викторовна
Publication year - 2013
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kmj1912
Subject(s) - endothelial dysfunction , renal function , medicine , decompensation , vascular endothelial growth factor , reactive hyperemia , effective renal plasma flow , vascular resistance , kidney disease , cardiology , urology , gastroenterology , renal blood flow , blood pressure , vasodilation , vegf receptors
Aim. This paper is devoted to the evaluation of clinical and diagnostic value of vascular endothelial growth factor detection in chronic pyelonephritis in children.Methods. The study included 62 patients with different compensation degrees of the disease. Patients were divided into 2 groups - subcompensation (37 patients), and decompensation (25 patients). Renal function was assessed by glomerular filtration rate. Vascular endothelial growth factor concentration was determined by the enzyme-linked immunosorbent assay. To assess the renal vasculature, triplex ultrasonography using pulsed Doppler was performed. The endothelial dysfunction was examined by postocclusion test with reactive hyperemia.Results. Vascular endothelial growth factor level had been significantly increasing in patients according to the severity of the disease. The vascular endothelial growth factor concentration exceeded 600 pg/ml all patients who has later developed chronic renal failure. The sensitivity of this indicator at the abovementioned critical point was assessed as 80%. The change of resistance index reflected renal vascularization disorders. The endothelial dysfunction in postocclusion test was also revealed in patients with pyelonephritis. The vascular endothelial growth factor level highly correlated with the glomerular filtration rate and resistance index.Conclusion. Detecting the vascular endothelial growth factor serum level is one of the tools for endothelial dysfunction laboratory monitoring and renal function assessment in in children with chronic pyelonephritis.