Open AccessVery premature babies and west’s syndrome
Author(s) -
N.R. Fatyhova,
Rimma Gamirova,
Л. Е. Зиганшина
Publication year - 2014
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kmj1447
Subject(s) - hypsarrhythmia , medicine , pediatrics , gestational age , periventricular leukomalacia , birth weight , low birth weight , spastic quadriplegia , west syndrome , cerebral palsy , epilepsy , pregnancy , physical therapy , psychiatry , biology , genetics
Aim. To compare the prevalence of West’s syndrome in very preterm babies and in babies with prematurity of 1-2 degrees.Methods. Both retrospective and prospective study including 241 preterm babies who received out-patient or in-patient aid for different neurological disorders. Inclusion criteria for the first group were diagnosis of a neurological disorder, gestational age less than 31 weeks and birth weight not exceeding 1500 grams. Inclusion criteria for the second group were diagnosis of a neurological disorder, gestational age of 32-37 weeks and birth weight ranging from 1501 to 2500 grams.Results. Severe central nervous system damage, including such conditions as spastic quadriplegia (126 out of 157 1stgroup babies, 80.3%, and 40 out of 84 2ndgroup babies, 47.6%, р 0.001), developmental delay of cognitive functions (123 out of 157 1stgroup babies, 78.3%, and 40 out of 84 1stgroup babies, 47.6%, р 0,001) were more common in the first group. West’s syndrome was diagnosed in 22 (14%) of cases in 1stgroup, in 3 (3.6%) of cases in 2ndgroup (HR=4.4, 95% CI [1.28; 15.16], χ2=6.42, р=0.01). In 21 (95.5%) of West’s syndrome cases, modified hypsarrhythmia was diagnosed by video electroencephalogram monitoring. Severe cerebral hypoxia of higher degrees, periventricular leukomalacia and hypoplasia of the corpus callosum were more common in 1stgroup babies.Conclusion. Our study showed that the prevalence of West’s syndrome in very premature infants with neurological disorders was 4.4 times higher compared to babies with prematurity of 1-2 degrees. There was an association between West’s syndrome in preterm babies and such cerebral disorders as severe cerebral hypoxia of 3rddegree, periventricular leukomalacia and hypoplasia of the corpus callosum.