Open AccessNeuroregulatory peptides in medicine
Author(s) -
Р. Д. Сейфулла,
M. V. Belous,
E. K. Kim
Publication year - 1989
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj99891
Subject(s) - receptor , action (physics) , diversity (politics) , character (mathematics) , functional diversity , peptide , pharmacology , toxicity , chemistry , neuroscience , computational biology , medicine , psychology , biology , biochemistry , ecology , mathematics , physics , geometry , quantum mechanics , sociology , anthropology
The wide spectrum of pharmacological activity, diversity of biological action, efficiency in low concentrations, absence of accumulation in the body, and low toxicity determine the prospects for the use of peptide bioregulators in clinical practice. At the same time, the existing obstacles in their use in practical medicine are caused by the rapid decomposition after administration, the modulatory character of their action, which depends on the initial functional state of the body, a weakly pronounced effect when taken orally, and the difficulty of crossing the blood-brain barrier. One approach to solving these problems is the targeted synthesis of new highly effective substances with selective and prolonged action, possessing the necessary stability and specific means to receptors along with natural peptides.