Open AccessLipid peroxidation and antioxidant system status in rheumatoid arthritis patients
Author(s) -
И. Г. Салихов,
K. N. Agisheva
Publication year - 1989
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj99854
Subject(s) - rheumatoid arthritis , lipid peroxidation , phagocytosis , chemistry , radical , hyaluronic acid , immune system , connective tissue , antioxidant , reactive oxygen species , chemotaxis , immunology , inflammation , biochemistry , medicine , pathology , receptor , anatomy
Recently, there has been significantly increased interest in the study of the role of free-radical lipid oxidation reactions in the development of the pathological process in rheumatoid arthritis. Immune complexes formed in this disease are a stimulus for neutrophil chemotaxis and initiation of phagocytosis reactions. The process of phagocytosis, accompanied by the release of a large number of reactive oxygen radicals, leads to damage of neutrophils themselves, release of lysosomal enzymes, degradation of collagen, hyaluronic acid and to connective tissue damage.