Clinical and pathogenetic aspects of viral hepatitis B

Viral hepatitis B is one of the key unsolved problems of modern medicine and is of great interest for clinicians of different profiles. Relevance of the problem is confirmed by high non-decreasing morbidity, possibility of severe course with the threat of fatal outcome, development of chronic forms of the disease, absence of reliable methods of etiotropic therapy. The study of hepatitis B became possible based on the verification of the diagnosis through the indication of specific markers of the virus, in particular its surface antigen (HBsAg). In our practice we have consistently used first-generation methods, firstly gel precipitation reaction (GPR) and counter immunoelectrophoresis (CEP), and later the highly sensitive methods, reverse passive hemagglutination reaction (ROPGA) and enzyme immunoassay (ELISA).