Open AccessMarkers of tumor cell proliferation in cancerous tumors of the larynx
Author(s) -
S. V. Petrov,
R. N. Kulagin,
Д. Э. Цыплаков,
O. V. Nefedov,
V. V. Saveliev,
A. R. Utkuzov,
N. T. Raikhlin
Publication year - 2022
Publication title -
kazanskij medicinskij žurnal
Language(s) - English
Resource type - Journals
eISSN - 2587-9359
pISSN - 0368-4814
DOI - 10.17816/kazmj99817
Subject(s) - larynx , mitotic index , cancer , proliferation index , cell growth , proliferating cell nuclear antigen , pathology , cell , squamous cell cancer , laryngeal neoplasm , medicine , cancer research , mitosis , biology , immunohistochemistry , anatomy , microbiology and biotechnology , genetics
The cell proliferative process in the larynx cancer is studied. Contrary to the classical mitotic index the Ki-67 and PCNA indices are reliable and reproducible on the clinical material by the proliferative cell activity indices of the larynx tumors. There is a reverse connection between the proliferation index in cells of the squamous larynx cancer and the tumor differentiation. The direct correlation of the cell proliferation index of the squamous laxynx cancer with the disease stage is revealed. The preoperative radiation therapy significantly decreases the cell proliferation rates of the squamous larynx cancer.